Is benzimidazole acidic or basic?
Is benzimidazole acidic or basic?
Benzimidazole is a base: C6H4N(NH)CH + H+ → [C6H4(NH)2CH] It can also be deprotonated with stronger bases: C6H4N(NH)CH + LiH → Li [C6H4N2CH] + H.
Is benzimidazole acidic?
Similarly, in aqueous solution benzimidazole is a stronger acid than imidazole, but its acidity decreases when dissolved in DMSO (pKa 16.8) or acetonitrile (pKa 25.6).
What is benzimidazole derivative?
Benzimidazole derivatives act by interfering with metabolic pathways. Parbendazole has been shown to exhibit a broad-spectrum Anthelmintic activity. This compound is the most potent of a series of substituted 2-amino derivatives, is active against a wide variety of animal nematodes [41].
Which acid is used in synthesis of benzimidazole?
Synthesis of benzimidazoles has been developed by the o-phenylenediamine with aldehydes using boric acid an efficient catalyst under mild reaction conditions in aqueous media.
What is the molecular formula of benzimidazole?
C7H6N2
Benzimidazole/Formula
Which of the following is the correct structure of benzimidazole *?
Benzimidazole | C7H6N2 – PubChem.
Is benzimidazole soluble?
The solubility of benzimidazoles in alcohols (C3−C6) is higher than in water and in 1-octanol and generally decreases with an increase of the alkyl chain length of the alcohol. The intermolecular solute−solvent interaction is higher for the 1-alcohol than for the secondary or tertiary alcohol.
Which solvent is used for recrystallization of benzimidazole?
Typical Procedure for the Preparation of Benzimidazoles After completion of the reaction, the reaction mixture filtered and washed with CH2Cl2 (15 ml) there time. If further purification was needed, by recrystallization it was dissolved in EtOH (10 mL) and then poured into ice water (30 mL).
What type of reaction mechanism is benzimidazole?
Principle: The two Carbon-nitrogen bonds in benzimidazole when disconnected give o-phenylenediamine and formic acid. Therefore, synthesis of benziemidazole is affected by simply heating the o-phenylenediamine and formic acid together (condensation type of reaction).
What is the molecular weight of benzimidazole?
118.14 g/mol
Benzimidazole/Molar mass
What is the pharmacological significance of benzimidazole ring?
The benzimidazole moiety is useful for the development of novel medicinal compounds in pharmaceutical field. Benzimidazole is also a vital pharmacophore, a privileged sub-structure in medicinal chemistry which contributes as a key part for different natural activities [2].
