What are the side effects of pertuzumab?

Common side effects of pertuzumab and trastuzumab

Risk of infection. This treatment can reduce the number of white blood cells in your blood.
Bruising and bleeding.
Anaemia (low number of red blood cells)
Effects on the heart.
Diarrhoea.
Feeling sick.
Loss of appetite.
Sore mouth.

What is the mechanism of action of trastuzumab?

As an antibody, one of the major mechanisms of trastuzumab is to attract immune cells to tumor sites that overexpress HER2, by a mechanism called antibody-dependent cellular cytotoxicity (ADCC).

How does pertuzumab work?

Pertuzumab works by locking onto HER2 on the cancer cells. It stops them from growing and kills them. Pertuzumab only works if your cancer is HER2 positive.

What is the difference between trastuzumab and pertuzumab?

Pertuzumab is a fully humanized monoclonal antibody which binds to domain II of HER2, essential for dimerization [27, 59], while trastuzumab binds to domain IV. Pertuzumab efficiently inhibits ligand-induced HER2/HER3 dimerization, whereas trastuzumab has only a minor effect in the presence of a ligand.

How effective is pertuzumab?

Pertuzumab has been shown to be safe and effective in metastatic and early HER2-positive breast cancer. Pertuzumab has been demonstrated to be effective for progressive growth against trastuzumab single-agent treatment for metastatic HER2-positive breast cancer.

Does pertuzumab cause neutropenia?

Nausea, rash and severe neutropenia also occurred in patients with pertuzumab-based therapies.

Is trastuzumab chemotherapy or immunotherapy?

These are active specific immunotherapy with Theratope and passive immunotherapy targeting the HER-2 receptor with trastuzumab (Herceptin). Trastuzumab has a proven efficacy as monotherapy as well as in combination with chemotherapeutic agents in HER-2-overexpressing metastatic breast cancer.

Is pertuzumab a monoclonal antibody?

Pertuzumab is a humanized monoclonal antibody targeting HER2 that is different from trastuzumab in that it binds to a different domain of HER2; hence, combining the two drugs leads to a more comprehensive blockade of the receptor.

Is pertuzumab an EGFR inhibitor?

Pertuzumab is a recombinant, humanized, monoclonal antibody that binds to the extracellular dimerization domain II of HER2 (located on the opposite side of the domain IV where trastuzumab binds). Pertuzumab inhibits heterodimerization of HER2 with EGFR, HER3, HER4 (Nahta et al.

Is pertuzumab a chemotherapy?

Pertuzumab is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as an “antineoplastic agent and a monoclonal antibody”. (For more detail, see “How Pertuzumab Works” below).

Does pertuzumab cause hair loss?

Pertuzumab and trastuzumab do not usually cause people to lose their hair. Any hair loss caused by chemotherapy should be temporary and in most cases your hair will begin to grow back once your chemotherapy has ended.

What are the side effects of pertuzumab?