What does CDX2 gene do?

What does CDX2 gene do?

Cdx2 regulates E-cadherin function indirectly by disrupting receptor tyrosine kinase activity and enhancing E-cadherin trafficking to the cell membrane compartment. Data indicate that CDX2 directly regulates MDR1 gene expression through binding to elements in the promoter region.

What are CDX2 cells?

The CDX2 protein is a homeobox transcription factor expressed in the nuclei of intestinal epithelial cells, playing an essential role in the development and function of the digestive system. CDX2 part of the ParaHox gene cluster, a group of three highly conserved developmental genes present in most vertebrate species.

Is CDX2 a transcription factor?

Cdx2 is a member of the caudal-type family of CDX homeobox genes and is the most well-known transcription factor involved in development and maintenance of trophectoderm.

Is Sox2 a protein?

Sox2 is a member of the Sox family of transcription factors, which have been shown to play key roles in many stages of mammalian development. This protein family shares highly conserved DNA binding domains known as HMG (High-mobility group) box domains containing approximately 80 amino acids.

What does CDX2 stand for?

Caudal-type homeobox 2 (CDX2) is an intestine-specific transcription factor with potential prognostic and predictive effect, but the importance in mCRC has not been fully investigated.

What kind of gene is SOX2?

SOX2 (SRY-Box Transcription Factor 2) is a Protein Coding gene. Diseases associated with SOX2 include Microphthalmia, Syndromic 3 and Septooptic Dysplasia. Among its related pathways are Oct4 in Mammalian ESC Pluripotency and Cytokine Signaling in Immune system.

What is the function of SOX2?

The SOX2 gene provides instructions for making a protein that plays a critical role in the formation of many different tissues and organs during embryonic development. The SOX2 protein is especially important for the development of the eyes.

What does positive for CDX2 mean?

These results suggest that positive CDX2 staining represents a highly sensitive and specific marker of metastatic colorectal carcinoma in both biopsy and resected specimens, and is superior to staining for the CK7-/20+ phenotype.

What does SOX2 stain for?

Sox2 is known to play an important role in maintaining the totipotency and self-renewal of embryonic stem cells. Indirect immunofluorescent staining of Sox2-overexpressing cells showed strong nuclear and diffuse cytoplasmic immunoreactivity for Sox2 in the antichicken Sox2 antibody-staining cells.

What is SOX2 marker?

SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult. Dev Neurosci.