What does proteolipid protein do?
What does proteolipid protein do?
Proteolipid protein (PLP) is the most abundant protein of central nervous system (CNS) myelin. Because of its predicted topography, PLP has been assumed to function as a structural component of myelin, providing stability and maintaining the compact lamellar structure.
What is PLP in medical terms?
Proteolipid protein: Abbreviation: PLP. Also called lipophilin. The most abundant protein of myelin, the covering and insulation around nerves. The mutations in PLP result in the loss of myelin that translates into the neurological problems.
What is PLP membrane?
Proteolipid protein (PLP or lipophilin) is a highly conserved, strongly hydrophobic, integral membrane protein, and is the major protein component of central nervous system myelin. These findings show that PLP can induce membrane ‘winding’ while preventing the fusion of adjacent lipid bilayers.
What is difference between lipoprotein and Proteolipid?
As nouns the difference between lipoprotein and proteolipid is that lipoprotein is any of a large group of complexes of protein and lipid with many biochemical functions while proteolipid is (biochemistry) any lipoprotein that is soluble in lipids.
What is PMD disease?
Pelizaeus-Merzbacher disease (PMD) is a rare X-linked genetic disorder affecting the central nervous system that is associated with abnormalities of the white matter of the brain and spinal cord.
What does DLP stand for in medical terms?
dyslipoproteinemia
List of medical abbreviations: D
| Abbreviation | Meaning |
|---|---|
| DLP | dyslipoproteinemia |
| DM | diabetes mellitus, Dermatomyositis |
| DM2 | Type 2 diabetes, formerly known as Non-Insulin Dependent Diabetes Mellitus (NIDDM). |
| DMARD | disease-modifying antirheumatic drug |
Which model of the cell membrane is used today?
Garth
Jonathan Singer and Garth Nicolson developed new ideas for membrane structure. Their proposal was the fluid mosaic model, which is the dominant model now. It has two key features—a mosaic of proteins embedded in the membrane, and the membrane being a fluid bi-layer of lipids.
Is Proteolipid a lipoprotein?
A proteolipid is a protein covalently linked to lipid molecules, which can be fatty acids, isoprenoids or sterols. They are not to be confused with lipoproteins, a kind of spherical assembly made up of many molecules of lipids and some apolipoproteins.
What are the symptoms of PMD?
Some symptoms an individual affected by PMD may experience could include but is not limited to muscle weakness, nystagmus (rapid, involuntary movement of the eyes), delays in motor development, feeding difficulties, breathing difficulties, muscle spasms, seizures, impaired cognition, dysarthria (speech difficulties).
What causes PMD?
The disease is caused by a mutation in the gene that controls the production of a myelin protein called proteolipid protein-1 (PLP1). PMD is inherited as an X-linked recessive trait; the affected individuals are male and the mothers are carriers of the PLP1 mutation.
What is HLP medical?
Hyperkeratosis lenticularis perstans (HLP) is a rare cutaneous disorder occurring in older persons and manifested by multiple benign pink to reddish-brown keratotic papules that primarily affect the extremities. The disorder was first described by Flegel (1958) (summary by Bean, 1972).
