What is drug knowledge?
What is drug knowledge?
Drug knowledge base, as an organic way of massaging and curating those different aspects of drug data, has been a popular research topic in biomedical informatics recently. A variety of drug knowledge bases have been developed to provide curated drug-related data.
What does PharmGKB do?
PharmGKB is an NIH-funded resource that provides information about how human genetic variation affects response to medications. PharmGKB collects, curates and disseminates knowledge about clinically actionable gene-drug associations and genotype-phenotype relationships.
What is DGIdb?
Abstract. The Drug–Gene Interaction Database (DGIdb, ) is a web resource that consolidates disparate data sources describing drug–gene interactions and gene druggability. It provides an intuitive graphical user interface and a documented application programming interface (API) for querying these data.
What is a pharmacogenetic study?
Pharmacogenetics, also called pharmacogenomics, is the study of how genes affect the body’s response to certain medicines. Genes are parts of DNA passed down from your mother and father. They carry information that determines your unique traits, such as height and eye color.
What is a drug knowledge base?
They range from simple ones with specific focuses to comprehensive ones that contain information on almost every aspect of a drug. These curated drug knowledge bases have made significant contributions to the development of efficient and effective health information technologies for better health-care service delivery.
What is pharmaceutical knowledge?
Micromedex® Pharmaceutical Knowledge provides trusted evidence for the pharmaceutical customer. It has advanced searching and provides the ability to compare and aggregate results with other information resources.
What is difference between pharmacogenomics and pharmacogenetics?
What is the difference between pharmacogenetics and pharmacogenomics? In general pharmacogenetics usually refers to how variation in one single gene influences the response to a single drug. Pharmacogenomics is a broader term, which studies how all of the genes (the genome) can influence responses to drugs.
What does PharmGKB stand for?
Pharmacogenomics Knowledge Base
The Pharmacogenomics Knowledge Base (PharmGKB) is a publicly available, online knowledge base responsible for the aggregation, curation, integration and dissemination of knowledge regarding the impact of human genetic variation on drug response.
What is druggable genome?
Approximately 3,000 genes are considered part of the “druggable genome,” a set of genes encoding proteins that scientists can or predict they can modulate using experimental small molecule compounds. Therefore, a large number of proteins remain for scientists to explore as potential therapeutic targets.
What is a gene drug interaction?
A Drug-Gene Interaction (DGI) is an association between a drug and a genetic variant that may affect a patient’s response to drug treatment. The selection of which DGIs to include in the PREDICT program starts with published evidence and FDA guidance.
What is a genetic drug?
Genetic medicines are genetic materials such as DNA and RNA delivered into the body as a therapeutic. They are a promising new class of medicine that was not possible even a short time ago.
