What is p53 antibody?
What is p53 antibody?
p53 Antibody (DO-1) is a high quality monoclonal p53 antibody (also designated tumor suppressor protein p53 antibody or TP53 antibody) suitable for the detection of the p53 protein of mouse, rat and human origin.
What happens when you phosphorylate p53?
Following stress, p53 is phosphorylated at multiple residues, thereby modifying its biochemical functions required for increased activity as a transcription factor. The biochemical functions include sequence-specific DNA binding and protein-protein interactions.
What happens when p53 is upregulated?
p53 upregulation was especially pronounced in neural cells and p53 inhibition reduced neuronal apoptosis. The mutants with upregulated p53 network had similar changes in several p53-dependent and independent molecular pathways.
What happens when you inactivate p53?
Inactivation of the p53 tumor suppressor is a frequent event in tumorigenesis. In most cases, the p53 gene is mutated, giving rise to a stable mutant protein whose accumulation is regarded as a hallmark of cancer cells.
What is the molecular weight of p53?
p53 is well known for its key role as a tumor suppressor protein. It is 393 amino acids (aa) in length with a predicted molecular weight of 44 kDa.
What proteins does p53 interact with?
One example of such regulation is the interaction of p53-family proteins with receptor Smads (R-Smads), intracellular transducers of TGF-β signaling. p53 binds Smad2 and Smad3, and cooperates synergistically with Smads to regulate transcription of a subset of TGF-β target genes.
How can I increase my p53 protein?
Vitamin C is able to increase the levels of p53 within colon cancer cells, according to a study published by the Korean Society for Biochemistry and Molecular Biology in 2011.
How does p53 work as a tumor suppressor?
If the DNA can be repaired, p53 activates other genes to fix the damage. If the DNA cannot be repaired, this protein prevents the cell from dividing and signals it to undergo apoptosis. By stopping cells with mutated or damaged DNA from dividing, p53 helps prevent the development of tumors.
Does p53 cause apoptosis?
P53 induces apoptosis in nontransformed cells mostly by direct transcriptional activation of the pro-apoptotic BH3-only proteins PUMA and (to a lesser extent) NOXA. Combined loss of the p53 effectors of apoptosis (PUMA plus NOXA) and cell cycle arrest/cell senescence (p21) does not cause spontaneous tumour development.
