What is the MAC value?
What is the MAC value?
The minimum alveolar concentration (MAC) value is the concentration of an inhalation anesthetic agent in the lung alveoli required to prevent movement in response to a surgical stimulus in 50% of patients.
What is time constant pharmacology?
Another time period that can be used to describe the curve is the time constant (τ). This is the point at which the elimination of drug would have been completed if the process had continued at its initial rate; it corresponds with a reduction in concentration to 37% of the original value.
What does a high MAC mean?
Meyer-Overton hypothesis MAC is inversely related to potency, i.e. high MAC equals low potency.
What is MAC Bar anesthesia?
The concept of MAC-bar is an estimate of the MAC of volatile anesthetic that blocks autonomic responses to surgical incision in 50% of patients. The autonomic responses commonly used to define MAC-bar are changes in pupil dilation, heart rate, and blood pressure.
Why are Macs Higher kids?
Children have a higher tolerance to the dysrhythmic effects of epinephrine during general anesthesia with volatile agents. In general, children have higher drug requirements (mg/kg) because they have a greater volume of distribution (more fat, more body water).
What drugs are used for MAC anesthesia?
MAC anesthesia
- midazolam (Versed)
- fentanyl.
- propofol (Diprivan)
Why is thiopental short acting?
As with all lipid-soluble anaesthetic drugs, the short duration of action of sodium thiopental is due almost entirely to its redistribution away from central circulation into muscle and fatty tissue, due to its very high lipid–water partition coefficient (approximately 10), leading to sequestration in fatty tissue.
What is the half-life of propofol?
Half-life: Propofol is bi-phasic, with its initial half-life being relatively quick, around 40 minutes, and its terminal half-life usually being 4 to 7 hours. Context-sensitive half-time may be up to 1 to 3 days after a 10-day infusion.
Is MAC considered general anesthesia?
General anesthesia refers to patients that are completely asleep and have an endotracheal tube down the throat. MAC anesthesia (Monitored Anesthesia Care) refers to patients that are not completely asleep (various levels of sedation) and were not intubated.
Is MAC considered deep sedation?
General anesthesia is often the first choice for surgical procedures, but even when MAC, rather than general anesthesia, is chosen, this deepest level of sedation is always an option, whether intentionally induced or not.
