Why does bortezomib work in multiple myeloma?
Why does bortezomib work in multiple myeloma?
What is bortezomib and how does it work? Bortezomib, formerly known as PS-341, is a boron containing molecule that specifically and reversibly inhibits the threonine residue of the 26S proteasome, an enzyme complex that plays a key role in the cell by regulating protein degradation in a controlled fashion.
What kind of inhibitor is bortezomib?
Bortezomib is the first approved proteasome inhibitor drug for the clinical treatment of cancer, and acts by reversibly inhibiting the proteasomal activity in addition to multiple oncogenic pathways in tumor cells.
How do proteasome inhibitors work for multiple myeloma?
Proteasome inhibitors are a type of drug that prevents proteasomes, the garbage disposal system of the cell, from chewing up excess proteins. The proteins build up and kill the myeloma cells.
What does Velcade do for multiple myeloma?
Generic Name: bortezomib This medication is used to treat certain types of cancer (such as multiple myeloma, mantle cell lymphoma). It works by slowing or stopping the growth of cancer cells.
What is the mechanism of action of bortezomib?
Mechanism of Action Bortezomib is a selective inhibitor of the 26S proteasome, preventing the activation of NF-κB. It induces apoptosis of rapidly dividing, metabolically active cells with extensive protein synthesis.
What is the role of bortezomib?
Bortezomib is used to treat people with multiple myeloma (a type of cancer of the bone marrow). Bortezomib is also used to treat people with mantle cell lymphoma (a fast-growing cancer that begins in the cells of the immune system). Bortezomib is in a class of medications called antineoplastic agents.
How is bortezomib given?
It is administered by a healthcare professional as an injection into your vein (intravenously, or IV) or under your skin (subcutaneously, or SC).
What happens if proteasome is inhibited?
Although normal cells make proteins, so do cancerous plasma cells – but they make much larger amounts of useless, ineffective protein. When a proteasome inhibitor stops this protein “recycling,” it allows the protein to build up until it blows the cell up. The cell dies of built-up bad, accumulated waste.
What is Multiple Myeloma?
Multiple myeloma is a cancer that forms in a type of white blood cell called a plasma cell. Healthy plasma cells help you fight infections by making antibodies that recognize and attack germs. In multiple myeloma, cancerous plasma cells accumulate in the bone marrow and crowd out healthy blood cells.
Why is dexamethasone used for multiple myeloma?
Dexamethasone and the other steroids are useful in myeloma treatment because they can stop white blood cells from traveling to areas where cancerous myeloma cells are causing damage. This decreases the amount of swelling or inflammation in those areas and relieves associated pain and pressure.
